Author: Francois

The Benefits of Following the Carbon in your Process Water

It’s well known that around 70% of the Earth’s surface is covered in water. It’s our most precious natural resource and great efforts have been made globally to protect the finite supply of water for the planet’s inhabitants. Growing population, climate change, and industrial contamination are some of the issues that cause water stress and impact water quality. This is why analytical testing to ensure water quality and safety is essential for health and the ecosystem.

There’s no denying that sustainability is a big topic for water management and resource conservation. As industries continue to prioritise eco-friendly practices, carbon monitoring will play a crucial role in achieving these goals, demonstrating a commitment to both innovation and environmental responsibility. But what does it mean to follow the carbon, and how does it benefit your operations?

 

What it means to follow the carbon

Following the carbon throughout your processes allows you to monitor processes or quality and pinpoint issues as they come about. Starting from the source water to the water that is used in the plant as utility and process water, and ultimately wastewater that is purified and discharged back into the environment, carbon monitoring can track the changing levels as the water moves throughout the facility and monitor levels if something goes awry. By monitoring carbon levels at each stage, facilities can gain valuable insights into their processes and quality control, enabling them to pinpoint issues as they arise and take timely corrective actions.

Download the eBook on the Power of Organics Monitoring >

Some of the benefits of following the carbon include:

Process optimisation – Facilities can improve the efficiency of the treatment process, reduce chemical use, and lower energy consumption.

Quality control – Continuous carbon monitoring helps maintain consistent water quality, which is critical for processes that require precise conditions, such as pharmaceutical production and food processing.

Regulatory compliance – Accurate carbon tracking provides the necessary data for regulatory reporting, demonstrating a facility’s commitment to environmental stewardship and compliance.

Let’s talk about TOC

Total Organic Carbon is a common measurement to gauge the amount of carbon-based compounds in water. TOC analysis aims to help corporations and municipalities reduce and optimise water use, comply with permit and regulatory requirements, and demonstrate safety and quality standards while maintaining asset reliability.

It provides reliable data and is written in many regulatory guidelines around the world and across various industries.

TOC and conductivity analysis aids in detecting chemical impurities in pharmaceutical-grade water systems and process equipment. Using TOC to understand the comprehensive cleanliness of water and equipment allows manufacturers to consistently deliver safe, high-quality drug products. Many TOC technologies work by oxidising organic molecules using UV or chemical oxidation and measuring the resulting CO2.

Watch our webinar on TOC and Conductivity Analysis: Back to Basics >

Water soluble compounds can be analysed using TOC analysis with little to no method variation. Compounds that do not readily solubilise in water can still be detected using small adjustments such as: agitation, pH, or temperature. With Sievers TOC Analyzers, consumables, and expertise from Veolia, you can be confident your method development will go smoothly.

The Veolia TOC-R3 Online Total Organic Carbon (TOC) and Total Nitrogen (TN) Analyzer is designed to solve critical industrial and environmental water challenges. From source water contamination and condensate leaks to wastewater optimisation and discharge, the TOC-R3 is a peace of mind analytical tool that provides responsiveness and repeatability.

Veolia TOC-R3 Online TOC Analyzer

Following the carbon in process water is an essential practice for modern industrial facilities. By systematically monitoring carbon levels, companies can protect their assets, optimise processes, maintain high-quality standards, and ensure regulatory compliance. This not only contributes to operational efficiency and cost savings but also supports environmental sustainability. As industries continue to prioritise eco-friendly practices, carbon monitoring will play a crucial role in achieving these goals, demonstrating a commitment to both innovation and environmental responsibility.

 

Technology to Improve Cannabis Testing

The cannabis industry is rapidly evolving, and with it comes a multitude of opportunities and challenges. The South African cannabis industry is also booming, driven by increasing demand for both medicinal and recreational cannabis products. Companies are developing various cannabis products, including oils, tinctures, and edibles. But this also means, as cannabis becomes more accepted and regulated, the need for accurate testing services grows.

A common misconception is that the sector is a straightforward cash cow for businesses, particularly in the realm of cannabis testing.

With regulatory requirements mandating thorough testing and the potential for high-profit margins, it might seem like a low-risk venture. However, newcomers should be cautious of pitfalls that can derail less experienced operators.

Quality in cannabis analysis

One of the most critical aspects of succeeding in cannabis testing is recognising the importance of quality. Setting up a laboratory with a strong emphasis on quality is not merely a regulatory necessity but a cornerstone for running a successful business. Quality in this context involves ensuring equipment reliability, accuracy and timeliness of results, staff training, reagent preparation, and method validation. By prioritising these elements, laboratories can minimise errors, enhance their industry standing, and build a solid reputation with customers.

Watch our webinar on Promoting Cannabis Lab Success >

 

Implementing a robust quality management system (QMS) is central to the operation of a high-functioning cannabis testing laboratory. A well-executed QMS produces high-quality, traceable data that stands up to audits and can be scrutinised if complaints arise. This system should be an ongoing effort to refine documentation practices, reduce errors, and improve testing processes.

Part of quality management is implementing the most effective methods for testing. eMethods are designed to accelerate your startup time by condensing the vast amounts of technical information and optimised analytical methods into a ready-to-run, downloadable, digital information package. What’s even better is that Agilent has done the hard work for everyone by creating eMethods that provides information on the instrument configuration, consumables, and Sample Preparation Protocols. eMethods also provide analytical methods for sample introduction, chromatographic separation, detection, and data analysis.
Compared to starting from scratch, an eMethod gives your lab a head start and gives you tips and tricks for best practices across all aspects of your workflow. If your lab is testing for pesticide residue, for example, an eMethod supplies the method for the separations and reliable detection of 72 pesticides and 5 mycotoxins in under 8 minutes.

Of course, you need great analytical instruments on which to run those methods. For new labs or labs moving into cannabis testing, it’s worthwhile to explore the latest technology in instruments. There’s great interest in ICP-MS which enables the analysis of trace metals in complex samples. As an example, The Agilent 7900 ICP-MS system helps you screen for target compounds in complex matrices – all within a single analysis. There are important questions to ask of an instrument supplier like Chemetrix when looking at the instruments for cannabis testing, like if sample types are measured, calculating the eventual cost per sample, if the software suits the instruments, and what technical support is offered. Chemetrix is able to provide confident answers to all these questions and more.

Download our checklist on How to Buy an ICP-MS for a Laboratory Analyzing Cannabis Products >

Getting your lab geared up correctly

The profitability of cannabis testing hinges on rapid sample turnaround and result delivery. However, the complexity of test requirements is increasing. To maintain quality and gain a competitive edge, labs must embrace digital transformation and adopt more efficient, accurate, automated, and scalable testing methods. Despite this, many cannabis testing labs still rely on manual processes, which are often error-prone, limited, tedious, risky, and slow.

Modernising with Agilent SLIMS addresses these issues, allowing labs to maximise the number of Certificates of Analysis (COAs) produced daily without compromising data quality. This capability enables labs to maximise revenue and scale operations with minimal risk. By reducing errors and enhancing efficiency, SLIMS helps labs meet regulatory requirements and customer expectations more effectively.

Along with great quality management software, Chemetrix is also able to offer testing solutions to laboratories within the cannabis industry. Chemetrix understands the demands of the production and manufacturing environments as well as the fact that cannabis is an emerging sector with smaller, more entrepreneurial labs coming to the fore. To help these labs grow, it’s important to find the right solutions that offer great return on investment and guarantee the highest levels of accuracy, efficiency, and data quality. Speak to our expert team to find out how Chemetrix can help your lab achieve its goals and learn more about our cannabis testing solution.

 

Imagining the Zero Waste Labs of Tomorrow

Scientific research laboratories play a crucial role in advancing our understanding of science and developing transformative healthcare solutions. However, the intensive nature of lab work has raised concerns about their environmental impact. These concerns primarily focus on energy consumption, waste production, chemical handling, and equipment disposal, all of which can leave a significant environmental footprint.

Life science research, in particular, is known for its high consumption of water and energy. Labs dedicated to addressing some of society’s most pressing challenges generate a disproportionate amount of waste. According to a study from the University of Exeter, nearly 5.5 million tons of plastic waste originate from labs, accounting for approximately 2% of all plastic waste globally.

In an era where global sustainability is of increasing importance, labs are facing the challenge of balancing scientific progress with ecological responsibility. Encouragingly, significant strides are being made in this area. A recent survey on lab sustainability by Frost & Sullivan revealed that 82% of the labs surveyed have adopted sustainability metrics. Impressively, 92% of these labs use these metrics to monitor resource use, and 87% have committed to goals aimed at reducing their global greenhouse gas (GHG) and carbon emissions. So, what are some of the key moves these labs are making to achieve these goals?

View the full survey on Reducing the Environmental Footprint of Research >

Reducing waste in labs

Waste management is a major environmental concern, with many labs recognising the need to reduce waste production. They are finding that even small, straightforward behavioural changes can lead to substantial results. Managing plastic waste, in particular, is a critical issue for labs.

Traditionally, plastic waste in labs is sterilised, incinerated, and transported over long distances, significantly contributing to carbon emissions. Furthermore, the incineration of plastic releases numerous toxic chemicals into the environment.

Watch our webinar on Boost Productivity and Eliminate Waste in Raw Material ID >

Fortunately, the market is seeing the development of innovative solutions for better plastic waste management in labs. One such solution is a sterilisation process that is over 90% more carbon-efficient, using a combination of mechanical and chemical processes. This innovative process eliminates the need for autoclave sterilisation, which disinfects plastic waste using heat—steam—along with pressure and time.

Download the The Carbon Impact of Biotech & Pharma Report >

Real-time monitoring of lab assets

Enhancing the management of lab systems and processes presents a promising opportunity for innovations that leverage the rapid advancement of digital tools. The cost-effectiveness of data monitoring and collection across various analytical instruments, along with the implementation of technologies such as artificial intelligence (AI) and machine learning (ML), can optimise asset usage and improve overall lab efficiency.

Future lab instruments will likely be equipped with features for monitoring and providing real-time feedback on their operational status. They will have built-in intelligence to alert lab technicians if there is an operational issue that needs attention or if consumables are running low. This real-time data will enable operators to make better-informed decisions, thereby optimising their lab assets for efficient management, superior scientific output, and sustainability benefits.

It is also important to analyse a lab’s end-to-end supply chain to ensure suppliers are being engaged that share similar sustainability values and provide transparency on their sustainability performance. Such choices are made easier by My Green Lab’s ACT label which provides information regarding the environmental impact of manufacturing, using, and disposing of a product and its packaging. One of the instrument that proudly carries this label is the versatile Agilent 1260 Infinity II LC System.

Watch this video to learn more about My Green Lab >

Agilent 1260 Infinity II Manual Preparative LC System

Re-educating lab staff

At every step, it is critical that lab technicians and support staff are educated and share the responsibility for using new technology and implementing sustainability policies. Having goals is essential, but they cannot be achieved without the collective efforts of the staff. They need to understand how to properly dispose of plastic waste, implement practices to reduce water and energy consumption and be inspired to seek new ideas and solutions to help labs achieve their sustainability goals.

Companies like Chemetrix and its suppliers, such as Agilent, provide a wide range of resources to support this educational effort. By fostering a culture of sustainability and equipping staff with the knowledge and tools needed to make a difference, labs can significantly reduce their environmental impact while continuing to advance scientific research.

Download the The Carbon Impact of Biotech & Pharma Report >

As we look to the future, it is possible that potential clients or potential contracts could be secured if there’s evidence that the lab operations are sustainable and waste reduction efforts are paying off. It’s become an influencing factor in business relationships as clients with their own sustainability initiatives want to know if their service providers or in-house labs are doing the same. For some labs, achieving sustainability and waste reduction goals can directly influence their operational budget. It could also boost efficiency and lead to innovation because it requires a different way of thinking that can spark fresh ideas. There’s so much to gain and nothing to lose from choosing to make a lab more sustainable and the rewards can be seen almost immediately and in years to come.

Exploring sustainability solutions and options can be daunting. It’s unknown territory and one can feel unsure about which option would work best for a specific lab. Chemetrix can help by hearing your sustainability challenges, and your lab goals, and finding the right instruments and consumables that’ll be a more eco-friendly choice. As labs endeavour to reduce waste, it’s helpful to trust Chemetrix to provide solutions and product suggestions that align with sustainability goals. Contact us and let’s make tomorrow possible today.

 

How Real is Your Milk?

The African dairy market is on the rise. Southern Africa plays a crucial role in this growth, with milk consumption gradually increasing in the region. Milk is a staple food in this region and is consumed in various forms, including fresh, powdered, and condensed milk.

The growth of the African dairy market is driven by factors such as changing consumer preferences, increased demand, and local special circumstances. The International Finance Corporation (IFC) projects that the African dairy sector will continue to grow by 30% which is drawing attention from investors.

Milk: The essentials

Milk is a natural source of the fats, minerals, nutrients, micronutrients, and vitamins required for a balanced diet. It is also essential for the growth and development of babies and infants into early childhood. Either breast or infant formula milk is given to babies for at least the first six months of their lives, and between the ages of one and two years, whole milk and dairy products are recommended to ensure that babies receive essential vitamins they may not otherwise obtain from lower fat alternatives.

 

Preserving nutritional values, safety, and authenticity

Milk and its related products are tested for three main reasons within the food and beverage industry:

  1. Nutrition — ensuring the required nutritional value of milk is present in its products.
  2. Safety — confirming the absence of suspected harmful chemicals in milk.
  3. Authenticity — determining if milk products are adulterated and therefore compromised in any way.

By testing these three factors, consumers are more protected from mislabelled, fraudulent, and potentially contaminated milk products that may have reached the marketplace unregulated.

The importance of testing nutritional values of milk and infant formulas

Testing the nutritional values of milk is important so that consumers can make informed decisions about their purchases. Above all, manufacturers of specified products — such as infant formulas for example — must adhere to uncompromising nutritional values determined by regional, national, or international regulatory bodies.

To support consumers making these decisions about their milk and/or infant formula purchases, it is crucial for manufacturers to label their products accurately. In doing so, food testing labs may carry out experiments using HPLC, LC/MS/MS, and GC systems to accurately measure milk content for sugars, fats, vitamins, and amino acids.

Measuring the levels of vitamins as well as beneficial (and some essential) elements such as sodium, potassium, magnesium, calcium, selenium, phosphorus, manganese, and zinc, provides insightful nutritional information. It’s also important to monitor for potentially toxic elements such as arsenic, cadmium, tin, mercury, and lead in animal-derived milk as contamination could originate from animal feed, fertiliser, soil, or processing equipment.

In one study, the Agilent 5800 VDV ICP-OES system used with an SPS 4 autosampler determined calcium, copper, iron, potassium, magnesium, manganese, sodium, phosphorous, and zinc in milk powder and infant formula samples according to the ISO 15151 method. Results showed that the recoveries for all analytes with certified or reference values were within ±10% of the expected value, thus confirming its nutritional labelling.

Other experimental examples include the rapid analysis of major and trace elements in milk and milk products using an Agilent 7900 ICP-MS with optional Ultra High Matrix Introduction UHMI technology and Integrated Sample Introduction System (ISIS 3).

Agilent 5800 ICP-OES
Agilent 7900 ICP-MS

 

Examining the safety of milk

Foods of animal origins such as dairy milk go through additional scrutiny to detect levels of veterinary drugs. Without a sophisticated approach for testing dairy milk samples, analytical challenges are likely to arise due to the complexity of the matrix and the number of pharmaceutical analogues needed to monitor. Furthermore, the different legislative requirements of various countries require sample referencing that meets a wide variety of regulatory conditions.

Watch our webinar on Food Testing Using Atomic Spectroscopy>

Another factor to consider when examining the safety of milk is the responsible use of pesticides within established limits in animal feeds from which dairy milk is extracted, and in other plant-based ingredients which may be added to other milk products. To validate this, LC/MS, GC/MS, and Q-TOF workflows offer food testing labs the solutions needed to accurately measure pesticide levels in milk samples.

Furthermore, food safety studies are routinely conducted to detect, quantify, and validate trace-level analysis of undesirable byproducts such as chlorate and perchlorate in store-bought milk and infant formulas. In one particular study, the Agilent 1290 Infinity II LC and Ultivo triple quadrupole LC/MS (LC/TQ) were utilised. Data from this experiment highlights accurate quantitation at one-tenth the level of the maximum residue level (MRL), which is 10 μg/kg in milk and infant formula as defined by the European Commission.

Download our poster on Quantification of Mycotoxins in Milk Samples >

Agilent 1290 Infinity II Online SPE System
Agilent Ultivo LC/MSMS

Exposing fraudulent milk to preserve its authenticity

Globally, milk continues to be one of the most adulterated food and beverage products on the market. For example, in 2008 the analysis of dairy milk powder from Minhe Hui County, China, revealed the contamination of melamine—an organic compound used to manufacture fertilisers and concrete—to be 500 times the maximum limit of melamine found in test samples at that time.

More recently in Southern Asia, the Punjab Food Authority seized almost 80,000 litres of milk to combat the adulteration of dairy products in the local metropolis. The milk was flagged due to the addition of urea and water.

In addition to deceiving consumers and manufacturing producers, food fraudsters can seriously affect the health outcomes of individuals. Fortunately, innovations in analytical instrumentation and testing methods are exposing these unlawful acts to reinstall consumer confidence by validating the authenticity and safety of products such as milk and infant formulas.

For example, the Agilent 8890 GC and the Agilent 5977B GC/MS single quadrupole mass spectrometer have been used to detect and quantify β-sitosterol in ghee (milk fat) samples to check for vegetable oil adulteration. The presence of β-sitosterol is associated with low quality and is a potential indicator of adulterated milk. Results showed that 2.24 ppm β-sitosterol was found in the ghee sample on which the study was performed.

Agilent 8890 GC

Both targeted and non-targeted approaches can be used to identify known compounds in milk and other food authenticity testing. The latter is beneficial if adulterants in milk are new or have not been previously identified by food testing labs. Non-targeted methods using quadrupole time-of-flight mass spectrometers, for example, create a chemical fingerprint of authentic foods, making it more difficult for food fraudsters to cheat the global food supply chain.

 

Forming partnerships to eliminate milk fraud

As milk sale projections are estimated to increase over the next few years, and with wider varieties of product choices in stores and online, it is important that companies like Chemetrix continue to work in partnership with its food testing customers to eliminate the threat of milk fraud while preserving its nutritional values, safety, and authenticity. Above all, manufacturers of milk products must adhere to multiple food regulations relating to quality and safety which are constantly being updated. Chemetrix is here to support our customers so that consumers of their products have confidence in their purchase choice for the nourishment of themselves and their families.

Parts of this article have been adapted from the original published by Agilent.

Bioburden Testing and Rapid Microbiology Methods

In the realm of pharmaceutical, medical device, and biotechnology industries, ensuring product safety and compliance with stringent regulatory standards is paramount. One of the critical quality control processes that aid in achieving this goal is bioburden testing. This essential procedure involves the quantification and identification of microbial load on products, packaging, and raw materials. At Chemetrix, we understand the significance of this process and the need for reliable and efficient instruments. This is where Veolia’s advanced solutions come into play, providing robust support for bioburden testing to enhance quality control measures.

 

 

What is bioburden testing?

Bioburden testing is the measurement of the microbial load, or the number of viable microorganisms present on a product, surface, or in a solution. This test is crucial in various stages of manufacturing, particularly for sterile products, as it ensures that the bioburden levels are within acceptable limits before sterilisation. By identifying and quantifying the microorganisms present, manufacturers can assess the effectiveness of their cleaning, disinfection, and sterilisation processes.

The results from bioburden tests are used to validate and monitor the manufacturing processes, ensuring that they consistently produce products that meet safety and efficacy standards. Regular bioburden testing helps in detecting contamination issues early, preventing potential product recalls and safeguarding consumer health.

The necessity of bioburden testing in quality control

Bioburden testing is not just a regulatory requirement but a critical aspect of quality control that offers numerous benefits:

  1. Ensures sterility: For products that must be sterile, such as medical devices, pharmaceuticals, and surgical instruments, bioburden testing ensures that the sterilisation processes are effective. Any surviving microorganisms can pose serious health risks to patients.
  2. Regulatory compliance: Regulatory bodies like the FDA and EMA mandate bioburden testing as part of the manufacturing process. Non-compliance can lead to severe penalties, product recalls, and damage to a company’s reputation.
  3. Process validation and control: Bioburden testing helps in validating and controlling manufacturing processes. By understanding the microbial load at various stages, manufacturers can fine-tune their processes to minimise contamination risks.
  4. Risk management: Identifying the types and quantities of microorganisms present allows for better risk management. This proactive approach helps in implementing corrective actions before any significant issues arise.

Watch our webinar on Testing Quality Attributes of Water for Pharmaceutical Production >

 

How Veolia’s instruments facilitate bioburden testing

Veolia offers a range of advanced instruments designed to streamline and enhance the bioburden testing process. Here’s how their technology can assist:

  1. Automated sampling and analysis: Veolia’s automated systems ensure precise and consistent sampling and analysis, reducing human error and improving reliability. These systems can handle high sample volumes efficiently, making them ideal for large-scale operations.
  2. Real-time monitoring: Veolia’s instruments offer real-time monitoring of microbial loads, providing immediate feedback on contamination levels. This capability allows for quicker decision-making and timely corrective actions, ensuring continuous control over the production process.
  3. Advanced filtration systems: Effective filtration is crucial in bioburden testing, and Veolia’s advanced filtration systems ensure that even the smallest microorganisms are captured and analysed accurately. These systems are designed to handle various sample types, from liquids to solids, ensuring versatility in testing.
  4. Comprehensive data management: Data integrity and traceability are critical in bioburden testing. Veolia’s instruments come with integrated data management solutions that ensure all test results are accurately recorded, stored, and easily accessible for audits and regulatory inspections.

 

 

Addressing bioburden effectively has yielded remarkable benefits across various industries, with numerous success stories underscoring its importance. Veolia’s cutting-edge bioburden testing instruments have played a crucial role in these successes. Their precision and efficiency in detecting and quantifying microbial presence have empowered companies to maintain stringent quality standards, ensuring the safety and efficacy of their products.

Download our whitepaper on Rapid Microbial Method Verification Testing for USP >

 

By investing in robust bioburden testing solutions, businesses can visualise a future where product recalls and contamination issues are drastically minimised. This proactive approach not only safeguards public health but also reinforces consumer trust, driving long-term growth and success. Embracing bioburden testing is not just a compliance measure; it is a strategic move towards achieving excellence in quality control and securing a competitive edge in the market.

Veolia’s state-of-the-art instruments offer unparalleled precision and reliability, empowering businesses to tackle microbial contamination with confidence. To learn more about how Veolia’s innovative solutions can enhance your bioburden testing processes and drive success, connect with Chemetrix today. Our team is ready to provide expert guidance and support, helping you achieve excellence in quality control and secure a competitive edge in the market.

 

Combating PFAS ‘The Forever Chemical’ Contamination

Per- and Polyfluoroalkyl Substances (PFAS) are a group of manufactured chemicals that have been used in industry and consumer products since the 1940s due to their useful properties. There are thousands of different PFAS, some of which have been more widely used and studied than others.

Nothing about PFAS – from how they are made, to their unique characteristics, to how they need to be analysed – is easy. These chemicals were developed to simplify our lives, but now decades later, they have become a serious problem due to their elusive and persistent nature, hence the nickname ‘The Forever Chemical.’ What is clear is that PFAS contamination is an environmental and growing health issue, but what is less clear is how to address and manage this issue.

 

The importance of PFAS

PFAS are important because they have been widely used in industry and manufacturing due to their unique chemical properties; properties that make them heat-resistant, able to repel water, and close to indestructible. PFAS compounds have been used in many applications such as non-stick cookware, stain-repellent clothes, food contact materials, detergents, cleaning products, and fire-fighting foams.

The unfortunate consequence of PFAS

For many years, PFAS were thought to be inert and nontoxic and were extensively used with little thought for environmental disposal or ecological impact. It was not until early this century that the extent of PFAS global contamination was first realised. There are over 4000 PFAS compounds thought to have been manufactured and are now potentially in the environment globally.

The research on PFAS compounds has identified them as being persistent and bio accumulative, and their widespread use has led to them being almost ubiquitous in the environment. Because PFAS do not break down, they enter the environment through production or waste streams. In South Africa, the presence of PFAS has been detected in some water sources, including rivers and dams.

“PFAS are a new style of pollutants that don’t follow the ‘rules’ of traditional organic pollutants. This is why regulators and scientists, unfortunately, failed to predict how these chemicals would move through the environment, and why we now have a serious problem of such widespread PFAS contamination of drinking water, agricultural land, and the domestic environment.”

– Bradley Clarke, senior lecturer in Analytical Chemistry and Environmental Science, at the University of Melbourne in Australia, and an Agilent collaborator.

 

PFAS exposure and human health

People can be exposed to low levels of PFAS compounds through consumer products that contain PFAS, for example, carpets, leather and apparel, textiles, paper and packaging materials, and non-stick cookware. Drinking water can also be a source of exposure in communities where these chemicals have contaminated water supplies, such as an industrial facility where PFAS were produced, or used to manufacture other products, or an oil refinery, airfield or other location at which PFAS may have been used for firefighting.

Download our eBook Guide to Targeted Quantification and Screening of PFAS Compounds in Environmental Matrices >

Helping scientists learn more about PFAS

PFAS contamination is a complex issue. While knowledge about PFAS compounds and their potential health effects has grown, many questions remain unanswered. It’s also a global issue and collaborative research allows countries to share knowledge, best practices, and effective solutions.

Watch our webinar on Strategies to Optimise Performance of PFAS Analysis >

Committed to helping scientists and regulators around the world solve these water issues to provide safe and sustainable water sources for everyone, Agilent has recently developed a protocol for the analysis of PFASs in drinking water using the Agilent Ultivo triple quadrupole LC/MS. Working with leading researchers around the world, Agilent has also developed a method for extracting PFASs in drinking water using Agilent Offline Solid Phase Extraction and an Agilent LC/MS/MS system with a PFAS-free 1290 Infinity II LC System.

Agilent Ultivo LC/MSMS

 

Agilent 1290 Infinity II 2D-LC System

 

Providing scientists with measurement and identification technology solutions to accurately analyze PFAS chemicals in water is a critical first step for estimating human exposure and potential risk. Robust analytical techniques that can provide unbiased quantitative and qualitative data on these PFAS pollutants at trace levels are necessary for further understanding their environmental fate, ecological impacts, and impacts on public health. These analytical techniques and the fundamental data they generate will allow scientists and regulators to make informed assessments of PFAS use in modern society.

Watch our webinar on The PFAS Lab of the Future >

Although PFAS research on the African continent is not extensive as yet, the growing awareness and need to understand these chemicals for policy and regulation is necessary. As an analytical instrument supplier and solutions provider for laboratories, Chemetrix is committed to helping combat the “Forever Chemical” challenge.

Parts of this article have been adapted from the original published by Agilent.

Revolutionising Nutrition: The Rise of Alternative Proteins

The food industry is experiencing a significant shift as alternative proteins rise in popularity. These non-animal-based foods, ingredients, and beverages, including plant-based, cell culture-based, and fermentation-based proteins, offer a new frontier in nutrition and sustainability. Designed to mimic the taste, texture, and nutritional profiles of traditional animal proteins, alternative proteins have come a long way from the mock meats of the past. The market for these products is booming, projected to surpass $290 billion by 2030, driven by their nutritional benefits, environmental sustainability, and potential to enhance food security.

Today, the industry for alternative proteins has technology on their side and are continuously turning to data and analysis to find solutions that will make these increasingly popular food items more appealing to a wider consumer base. And while meat or burgers grown in a lab does grab headlines, it’s a far cry from the products found in grocery stores that are more practical and cost-effective. Making better alternative protein products isn’t as easy as throwing lentils into the mix and scientific methods are helping to expand the alternative protein offerings in the mainstream market.

 

Passing taste tests with lab innovation

As the market for alternative proteins expands, rigorous testing becomes crucial. Ensuring the safety, composition, health benefits, and sustainability of these products is essential for maintaining consumer trust and industry growth. For many consumers, concerns about contaminants like veterinary drugs and hormones in meat products make alternative proteins a preferred choice, perceived as a healthier option. However, with rising demand and sometimes limited supply, food fraud becomes a significant challenge. Fraudsters may substitute expensive plant-based proteins with allergens like wheat or soya, or engage in other deceptive practices such as mislabelling and counterfeiting.

To address these challenges and meet consumer expectations in terms of the sensory experience, food developers are turning to advanced analytical tools. These tools are essential for overcoming the biggest hurdles to mainstream acceptance of alternative proteins: taste and texture.

By using sensitive instruments to analyse and optimise the flavour, aroma, and nutritional profiles of these products, food scientists can ensure they meet the high standards expected by consumers.

The process begins with sample preparation to remove unwanted interferences such as fats, chlorophyll, and pigments, allowing researchers to accurately compare the alternative proteins to their animal-based counterparts. Tools like liquid chromatography and mass spectrometry systems are then used to analyse food on a molecular level. Liquid chromatography provides detailed characterisation of stable components such as amino acids, vitamins, and lipids, while gas chromatography examines volatile compounds to engineer desired smells and tastes.

In addition to instrumental analysis, human taste testers play a crucial role in evaluating the palatability of food. Advanced instrumentation can complement this by objectively identifying the five basic tastes – sweet, salty, sour, bitter, and umami – in alternative proteins. This combined approach ensures a comprehensive assessment of flavour and texture, critical for consumer acceptance.

Download our Application Compendium for tips and tricks on Alternative Protein Testing >

Ensuring a quality composition of alternative proteins

Agilent’s workflow solutions exemplify the robust testing needed in the alternative protein industry. These solutions validate the authenticity, nutritional information, and safety of alternative protein products. For instance, Agilent’s LC-Q-TOF-MS/MS technology has been used to investigate non-meat proteins and peptide markers in ready-to-cook beef burgers, while GC/MS-based metabolomics approaches differentiate the chemical profiles of plant-based meat alternatives from grass-fed ground beef.

Watch our webinar on Metabolomics Profiling of Meat and Plant-based Meats >

 

Agilent 5977 GC/MSD

 

Elemental analysis is another critical aspect of ensuring the quality of alternative proteins. During the production process, there is potential for elemental metals to contaminate the final products. Agilent’s atomic spectroscopy instruments, such as the 7850 inductively coupled plasma mass spectrometry (ICP-MS), enable the identification and quantification of these metal elements, ensuring product safety.

Agilent 7850 ICP-MS

 

The future of food relies heavily on advancing research into alternative proteins. Technologies such as ICP-MS, triple quadrupole (QQQ) liquid or gas chromatography-mass spectrometry (LC/GC/MS), and high-performance liquid chromatography (HPLC) are recommended for robust testing purposes. These tools not only support the development of safer, healthier, and more sustainable food options but also influence the global food supply chain.

 

Chemetrix has the expert knowledge and innovative solutions required by the food industry to advance the safety and innovative product development of alternative proteins. As the food and agriculture industry faces ever-increasing demands for more sensitive, productive analytical solutions, Chemetrix leads the industry with products and services to help you deliver what your customers demand. Our instruments, systems, and supplies are used throughout the food production chain, including incoming inspection, new product development, quality control and assurance, and packaging. Contact us to find out how our team can assist you.

 

Analyse Microplastics in Minutes, Not Hours

Want to bring exceptional speed and throughput to your microplastics research?

Microplastics in the environment are becoming a greater concern as scientists begin to understand their penetration into our ecosystems and food chains. Typically, techniques such as vibrational spectroscopy have been used to chemically identify microplastics. However, this approach is often complex and slow.

What you will learn

The Agilent Laser Direct Infrared (LDIR) chemical imaging system introduces an automated approach to imaging and spectral analysis. Its Quantum Cascade Laser (QCL) technology—coupled with rapidly scanning optics—provides fast, high-quality images and spectral data. Using the 8700 LDIR, experts and non-experts alike can:

  • Analyse samples in minutes, not hours.
  • Determine the chemical identity, size, and shape of microplastics in their samples.
  • Obtain useful statistical data to advance their microplastics research.
  • Take rapid, detailed images of large sample areas with intuitive Agilent Clarity software.

 

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Mitigating Plastic Pollution While Regenerating Our Oceans

It is estimated that more than 75% of the 8.3 billion metric tons of plastic produced over the last 65 years have turned into waste, of which up to 13 million metric tons end up in our oceans every year.

Plastic is one of the most enduring materials created by humans. Unfortunately, it can take hundreds of years to degrade, and even then, it often becomes microplastics – tiny particles that can be ingested by marine animals. These microplastics enter the food chain, leading to disastrous consequences for our planet and its inhabitants.

Improving plastic waste management globally is critical and individuals and organisations can play a part in reducing plastic pollution and regenerating oceans. Researchers are exploring biodegradable plastics and alternative materials to reduce plastic’s impact and there are many alternative solutions available to reduce single-use plastics.

 

What labs are doing to reduce plastic pollution

Labs can be influential advocates and encourage industry-wide shifts toward more sustainable practices. Of course, labs are key players in the research of plastic pollution, analyzing to help organisations develop a better understanding of the scope of plastic waste worldwide and use those insights to create innovative solutions, especially for marine environments.

But there’s also no denying that labs consume vast amounts of single-use plastic items, including pipette tips, tubes, gloves, and reagent bottles. These plastics are essential for maintaining sterile conditions and avoiding contamination, but their disposal contributes significantly to plastic waste. Lab instruments are also made up of plastic parts and do most of us know the process for disposing of those instruments at the end of their life?

What’s exciting to see is the scientific community strongly advocating for change and implementing practices that already have a significant impact such as:

  • Reviewing the materials used in common consumables and opting for products with minimal plastic content or those made from recyclable materials.
  • Incorporating re-using along with recycling and engaging with suppliers to support re-useable product options and recycling programs
  • Designing experiments and workflows with circular economy principles in mind.
  • Setting targets for reducing plastic waste.

 

An example of plastic sustainable solutions

With a focus on forming a biotech company to tackle plastic pollution, ULUU was started in 2020 by Dr Julia Reisser and Michael Kingsbury. They are trying to solve the growing issue of plastic pollution by prototyping alternative materials to market.

ULUU’s PHA product sample

 

“Unlike synthetic plastics, our materials are not produced using petrochemicals derived from fossil fuels. Instead, they are made from sustainable feedstocks with much more sustainable production processes. And, in the end, our products are compostable and marine-biodegradable, so they don’t pose a lasting impact on the environment,” described Dr. Luke Richards, lead scientist at ULUU.

The mission at ULUU is to replace plastics with materials that are good for the world. They’re producing a versatile natural polymer called polyhydroxyalkanoates (PHA), using seaweed as a sustainable resource for that process. The result is a material that is biodegradable and won’t accumulate in oceans and landfills or linger as microplastics in biological systems.

Discover the Challenges in Microplastics Analysis in our webinar >

ULUU scientists Dr Sheik Md Moniruzzaman and Vatsal Meshram in their QC lab using the Agilent 1260 Infinity II LC with Agilent InfinityLab LC/MSD iQ

 

In terms of climate change, using seaweed as a feedstock, ULUU captures carbon dioxide from the atmosphere and converts it into PHA. Their process also doesn’t rely on conventional land-based farming, which can take land away from natural ecosystems. Additionally, farming seaweed has some positive impacts on oceans. Research indicates that seaweed helps clean up environmental pollutants and reverses acidification and eutrophication.

ULUU uses bioreactors ranging from 1 to 50 L to make their products. They also use specialised equipment to investigate injection moulding and turn their PHA product into solid objects for prototyping. The entire production process from seaweed input to the finished PHA powder is monitored by their QC lab, in which most assays use chromatography instruments. These instruments include two Agilent 1260 Infinity II liquid chromatographs (LCs) and one Agilent 8890 gas chromatograph (GC), with detection by an Agilent InfinityLab LC/MSD iQ, an Agilent 1260 Infinity II refractive index detector (RID), and an Agilent 5977B GC/MSD.

Agilent 8890
Agilent LC/MSD iQ
Agilent 1260 Infinity II
Agilent 5977B GC-MSD

 

Sustainability is the way of the future for all laboratories and investing in the right solutions now can turn the tide for the future. Chemetrix is the partner labs that need to reach its sustainability goals and implement solutions that will reduce its environmental impact and plastic waste now and in years to come.

 

Free Your Workflows from Common Time Traps

The smarter way to avoid time traps in your laboratory.

Do you think time-consuming tasks in ICP-MS are inevitable? Something that has to be accepted as part of routine operations? Find out how ICP-MS 7850 helps you easily meet your analytical requirements while simplifying laboratory workflow and improving performance and satisfaction for analysts and laboratory managers.

The intelligence embedded in the ICP-MS 7850 provides a more efficient way to perform metal analysis by reducing unnecessary wasted time so that your staff can focus on activities that generate greater value for the laboratory.

 

What you will learn

  • Simplify the preparation of your samples and standards.
  • Facilitate the implementation of analytical methods and the handling of the instrument.
  • Improve confidence in your results whatever the matrix analysed
  • Maintenance operations and reduce instrument downtime
  • Optimise and obtain better instrument and sample insights

 

Date: Thursday, June 14, 2024
Time: 01:00 PM – 02:00 PM (GMT)
Speaker: Dr. Raimund Wahlen, Product Specialist, Agilent Technologies

 

Register now >