Ensuring Food Safety with Mass Spectrometry

In an interconnected world where food production and trade span continents, ensuring the safety and quality of food products has become a critical priority. Rising consumer expectations and increasingly stringent regulatory standards mean stakeholders in the food industry must navigate a complex web of challenges. From detecting contaminants to meeting compliance requirements, the stakes are high. This is where cutting-edge technologies like mass spectrometry are stepping in to revolutionise food safety testing, delivering unmatched precision, efficiency, and reliability.

 

The growing importance of Food Safety

Food safety is non-negotiable. Defined by the World Health Organization (WHO) as the prevention of hazards – both chronic and acute – that can harm consumer health, it forms the backbone of a trustworthy food supply chain. Hazards may include microbial contamination, pesticide residues, heavy metals, and even naturally occurring toxins, all of which can pose serious risks if left unchecked.

Food quality, while often considered alongside safety, addresses different concerns. It encompasses attributes such as flavour, texture, appearance, and even the origin of a product. While safety ensures a product is fit for consumption, quality determines its value and appeal to consumers.

For food producers, striking a balance between these two aspects is essential to building trust and maintaining competitiveness.

 

Why Mass Spectrometry?

Mass spectrometry has become a cornerstone of modern food safety testing, thanks to its unparalleled sensitivity, accuracy, and versatility. Unlike traditional methods, which may require separate tests for different contaminants, mass spectrometry can detect and quantify multiple analytes in a single run. This capability significantly enhances efficiency and reduces the time required for analysis – a critical advantage for laboratories handling high sample volumes.

 

Key Advantages of Mass Spectrometry in Food Safety

Unmatched sensitivity and precision

Mass spectrometry can detect contaminants at trace levels, often in parts per billion (ppb) or even parts per trillion (ppt). This is vital as regulatory agencies worldwide demand more stringent detection limits to protect public health.

Multi-analyte detection

With mass spectrometry, laboratories can analyse multiple contaminants simultaneously, including pesticides, heavy metals, mycotoxins, and allergens. This not only improves throughput but also reduces the cost and complexity of testing.

Simplified sample preparation

Advanced mass spectrometry systems streamline sample preparation, reducing the likelihood of human error while speeding up the testing process.

Adaptability across food matrices

From solid foods like grains and meats to liquids like milk and juices, mass spectrometry can handle diverse food matrices, making it a versatile solution for the food industry.

 

📚 Download the Food Safety Applications in Mass Spectrometry primer for a practical reference for applying current developments in Agilent MS technologies to food analysis: https://chemetrix.co.za/wp-content/uploads/2024/12/5989-1270EN-AGI_74_combined.pdf

 

Transforming Food Safety Testing

One of the most significant developments in mass spectrometry is the rise of inductively coupled plasma mass spectrometry (ICP-MS). Historically viewed as complex and challenging to operate, ICP-MS has undergone a transformation. Modern instruments now feature user-friendly interfaces, automated optimisation, and built-in diagnostic tools, making them accessible to labs of all sizes.

ICP-MS is particularly valuable for detecting heavy metals such as lead, cadmium, and mercury, which can have severe health consequences even at low concentrations. The technique’s sensitivity and specificity ensure that contaminants are accurately identified and quantified, enabling producers to meet regulatory requirements with confidence.

Another breakthrough is the integration of liquid chromatography-mass spectrometry (LC-MS) and gas chromatography-mass spectrometry (GC-MS). These methods are widely used for detecting pesticide residues and volatile organic compounds in food products. The combination of chromatography and mass spectrometry allows for the separation and precise identification of compounds within complex mixtures, ensuring reliable results.

Agilent 7000D Triple Quadrupole GC-MSMS
Agilent 6495C LC/MSMS

📚 Download the Improving Food Safety Analysis with LC/Q-TOF compendium of application notes and explore analysis of pesticides, nontargeted screening approaches for contaminants, and food authenticity testing: https://chemetrix.co.za/wp-content/uploads/2024/12/Improving_Food_Safety_Analysis-with-LC_Q-TOF-Feb2020.pdf

 

Addressing the challenges of a globalised food supply chain

In a globalised food economy, the complexity of supply chains adds another layer of risk. Ingredients sourced from diverse regions can introduce contaminants at various stages, making robust testing protocols indispensable. Additionally, the transportation and storage of food products can create opportunities for microbial growth or chemical alterations.

Regulatory bodies worldwide, such as the European Food Safety Authority (EFSA) and the United States Food and Drug Administration (FDA), have responded by tightening standards and lowering acceptable thresholds for contaminants. As a result, food manufacturers must adopt advanced technologies to stay ahead of compliance requirements.

Mass spectrometry provides the tools needed to address these challenges. Offering rapid, reliable testing, enables stakeholders to identify potential issues early in the supply chain. For example, a shipment of imported spices can be tested for pesticide residues before distribution, preventing contaminated products from reaching consumers.

Moreover, mass spectrometry supports traceability – a key component of modern food safety systems. By linking test results to specific batches or production lots, producers can quickly identify and recall affected products in the event of a safety breach. This level of accountability is essential for maintaining consumer trust and avoiding costly disruptions.

📚 Download the Multi-Residue Pesticide Analysis in Food Matrices poster to see how the screening and quantitation of 250 pesticides was done using the Agilent Ultivo Triple Quad: https://chemetrix.co.za/wp-content/uploads/2024/12/Multi-Residue_Pesticide_Analysis-_Food_Matrices_Ultivo_AOAC_2017_PW044.pdf

 

Chemetrix: Your partner in Food Safety

Chemetrix is at the forefront of delivering advanced mass spectrometry solutions tailored to the needs of the food industry. With a deep understanding of the unique challenges faced by producers, regulatory agencies, and testing laboratories, Chemetrix provides comprehensive support to ensure optimal performance and compliance.

Why choose Chemetrix?

  • Cutting-Edge Instrumentation: Chemetrix offers state-of-the-art mass spectrometry systems, including ICP-MS, LC-MS, and GC-MS, designed for precision and efficiency.
  • Expert Guidance: From installation to training and ongoing support, Chemetrix’s team of experts ensures that clients can fully leverage their technology investments.
  • Tailored Solutions: Recognising that every client has unique requirements, Chemetrix works closely with stakeholders to develop customised workflows that meet their specific needs.

By partnering with Chemetrix, food producers and testing labs gain access to the tools and expertise needed to navigate the complexities of modern food safety testing with confidence.

 

The Future of Food Safety

As food systems evolve, so too must the methods used to ensure their safety. Mass spectrometry represents a critical step forward, offering the precision, speed, and adaptability needed to meet the challenges of an increasingly interconnected world.

For the food industry, adopting advanced testing technologies is not just about compliance – it’s about safeguarding public health, protecting brand reputation, and building trust with consumers. With partners like Chemetrix leading the way, the future of food safety is brighter, more secure, and more innovative than ever.

The Importance of Biopharma Analytical Testing

In the world of biopharmaceuticals, precision and safety are non-negotiable. As companies work to develop advanced therapies and biologics, the role of analytical testing becomes ever more critical. Analytical testing serves as the backbone of biopharma development, ensuring that every product released to the market meets stringent regulatory standards while maintaining the highest safety and efficacy levels. Chemetrix supports this vital process by equipping laboratories with state-of-the-art technologies to optimise testing workflows and ensure regulatory compliance.

 

Why Analytical Testing Matters in Biopharma

Biopharmaceutical products, including monoclonal antibodies, cell and gene therapies, and vaccines, are inherently complex. Unlike traditional small-molecule drugs, these products are often derived from living cells, making them highly sensitive to variations in manufacturing and storage conditions.

Analytical testing ensures the quality, purity, potency, and stability of biopharmaceuticals throughout their lifecycle, from early development to final product release.

Without rigorous testing, even minor inconsistencies in a product can lead to reduced efficacy, compromised safety, or regulatory non-compliance. By employing advanced analytical methods, biopharma companies can identify impurities, confirm molecular structures, and monitor critical quality attributes (CQAs) that are essential for maintaining product integrity.

📚 Download The Journey to Biopharma infographic to discover streamlined automation and cutting-edge analytics >

 

Key Phases of Analytical Testing

Early development

During the early stages of biopharma development, testing focuses on characterising the biological product and defining CQAs. Techniques such as mass spectrometry, high-performance liquid chromatography (HPLC), and spectroscopy play a central role in these analyses. These tools help determine factors like molecular weight, structural integrity, and glycosylation patterns.

Process development

As manufacturing processes are developed, analytical testing ensures consistency and scalability. Process-related impurities, such as host cell proteins or residual solvents, must be identified and quantified. Additionally, methods like capillary electrophoresis and liquid chromatography-mass spectrometry (LC-MS) are employed to optimise purification steps and ensure process robustness.

Final product release

Before a product reaches the market, it undergoes comprehensive testing to confirm that it meets regulatory specifications. This includes assays for potency, sterility, endotoxin levels, and stability. Modern analytical platforms, such as multi-mode plate readers and automated systems, provide the throughput and accuracy needed for these critical assessments.

 

Trends in Analytical Testing for Biopharma

Emergence of advanced techniques

The biopharma industry is increasingly adopting technologies like LC-MS and next-generation sequencing (NGS) to enhance analytical capabilities. These methods allow for greater sensitivity and specificity, enabling researchers to detect low-level impurities and subtle molecular changes that could impact product performance.

Adoption of automation and AI

Automation is transforming analytical testing, reducing human error and increasing throughput. AI-driven software is also being integrated into testing workflows, enabling predictive analytics and more efficient data interpretation.

Focus on emerging therapies

The rise of cell and gene therapies has introduced new challenges for analytical testing. These therapies require novel analytical approaches to address their unique complexities, such as the characterisation of viral vectors and the assessment of genome editing outcomes.

Regulatory compliance and data integrity

With stringent guidelines from organisations like the FDA and EMA, ensuring data integrity has become a top priority. Advanced software systems with audit trails and robust data management capabilities are increasingly essential in biopharma testing.

📚 Watch the Accelerating Analysis in the BioPharma Laboratory​ webinar to discover biopharma workflow innovations that accelerate the characterisation or pathway profiling in protein work & proteomics research using liquid chromatography Mass Spec >

 

Driving excellence in Analytical Testing

Chemetrix is at the forefront of supporting biopharma companies with advanced analytical solutions. By offering cutting-edge instruments and technologies, we help laboratories address the challenges of testing biologics and other complex products.

We provide access to industry-leading platforms, including HPLC systems, LC-MS, and next-generation spectroscopy tools. These technologies are designed to deliver high sensitivity and precision, ensuring that every aspect of a biopharmaceutical product is rigorously tested.

The new generation Agilent 1260 Infinity III is a robust instrument that delivers the performance, reliability, and robustness you need for the highest confidence in daily HPLC results. With the freedom to mix and match new modules with existing HPLC instrumentation, it’s possible to maximise uptime and minimise disruption while also getting on the fast track to efficiency, optimizing speed and resolution for analysis.

Agilent 1260 Infinity II

Moreover, Chemetrix offers comprehensive support services, from installation and training to ongoing maintenance and technical assistance. This ensures that labs can maximise the performance of their analytical equipment and stay ahead of industry demands.

📚 Download the Mass Spectrometry of Macromolecules Using Standard Flow LC/MS application note to discover a robust and sensitive LC/MS method using standard LC flow for the analysis of native protein analysis >

 

The importance of analytical testing in biopharma cannot be overstated. As the industry continues to evolve, the need for advanced testing methods will only grow. By leveraging state-of-the-art technologies and partnering with trusted providers like Chemetrix, biopharma companies can ensure the safety, efficacy, and quality of their products while meeting regulatory expectations. With our commitment to innovation and excellence, Chemetrix stands as a trusted ally for laboratories navigating the complexities of biopharma analytical testing.