In modern production of small molecule pharmaceuticals, biopharmaceuticals, and, in fact, ALL production batches, the reaction has to be closely monitored and potentially even controlled by, for instance, online reaction monitoring analytics. Therefore, connecting a UHPLC instrument by a sampling device to the reaction vessel can be helpful. The 1260 Infinity II Prime Online LC offers a combined UHPLC and integrated reactor sampling interface for automated reaction sample analysis with the Agilent 1260 Infinity II Online Sample Manager. This device enables the drawing of samples from a reactor and dilution/quenching prior to an injection.
This presentation will include a look at the hardware and software used for the Agilent OnLine LC system. We will log into a live system to view the setup possibilities and review data acquired on the system.
Agilent Technologies, Inc.
Bob Giuffre has been working with HP/Agilent for almost thirty years as an Application Scientist for the HPLC product line. During that time Bob has worked on applications ranging from small molecule pharmaceutics to large molecule polymers, to monoclonal antibodies. Currently, Bob is working in the area of ultra-high pressure two-dimensional liquid chromatography as a means to increase peak capacity for complex formulations. Bob has authored a chapter on the use of Diode-Array Detection in Pharmaceuticals. He is currently writing a chapter on Troubleshooting Peptide and Proteins Analysis using LC-MS.