Agilent BioTek 406 FX Microplate Washer Dispenser: Technology-Driven Application Diversity and Workflow Efficiency

Introducing Agilent BioTek’s new 406 FX microplate washer dispenser. Built on decades of innovation and success, the 406 FX is the latest advancement in microplate washing and dispensing. The 406 FX integrates parallel peristaltic and syringe pump dispensing with microplate assay washing within a singular platform. The compact design of the 406 FX delivers fast, full-plate washing along with six reagent dispensers. From basic ELISA, to sensitive cell washing, to biomagnetic bead washing, the 406 FX offers modules to address a myriad of assay requirements and workflows.

The automated microplate dispensers perform across a range of volumes offering simple, repeatable, and precise liquid delivery. Modular peristaltic and syringe pump dispensers help to meet varied liquid handling requirements, catering to the broadest spectrum of assay workflow requirements. This multidisciplinary tool enables researchers to drive a diverse spectrum of applications while maintaining workflow efficiency.



Dr. Charles William Amirmansour
Global Business Development Manager
Agilent Technologies, Inc.

Dr. Amirmansour is a Global Business Development Manager (Cell Analysis Division at Agilent BioTek) who offers a unique set of skills, creating cutting-edge business development programs, with an extensive background across the Life Science and Drug Discovery domain. Additionally, his strong academic and industry experience resonates with research-based microplate and assay technologies. His academic career started when he received his undergraduate degree at King’s College London (University of London) whilst gaining research experience at The William Harvey Research Institute (Queen Mary University of London) under the supervision of Nobel Laurate, Prof. Sir. John Vane. He then obtained his doctorate in Clinical Pharmacology from University College London (under the joint supervision of Prof. Sir Patrick Vallance and Prof. Sir Salvador Moncada). Finally, Dr. Amirmansour held two Post-Doctoral positions at The National Heart & Lung Institute and Harefield Heart Science Centre (Imperial College London), respectively under the supervision of world-renowned pioneering cardiothoracic surgeon and Lister Medal awardee, Prof. Sir Magdy Yacoub.


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High-Throughput Intact Native Protein Analysis

Ion mobility-mass spectrometry has become a valuable analytical tool in native protein analysis. In protein structure studies, ion mobility spectrometry provides rotationally averaged collision cross-section values that correlate to size and shape of the biomolecule. For proteins, ground state CCS and accurate mass are not adequate to identify different proteins. Therefore, the introduction of gas phase unfolding followed by ion mobility measurements provide unique fingerprints for native protein analysis. This collision-induced unfolding (CIU) technique can be utilized to identify proteins and protein complexes. Typical CIU experiments utilize static nano-ESI or standard ESI using a syringe pump for sample introduction which is difficult to automate. In this study, we have developed a new automated sample introduction method for high-throughput CIU experiments which can be adapted for IgG and other proteins.


Sheher Banu Mohsin, Ph.D.
Senior Applications Scientist
Agilent Technologies, Inc.


Sheher Mohsin is a senior applications scientist at Agilent Technologies. She received her Ph. D in physical chemistry from the University of Illinois and an MBA from Rockhurst University. She started her career at the US Environmental Protection Agency working on dioxin analysis with high-resolution mass spectrometers. She later joined Bayer and worked in the special analysis lab using mass spectrometry to solve problems in synthesis, impurity determination and submission of final product impurity profile to regulatory agencies. Sheher’s current focus is on lipidomics using GC, LC and SFC separations and mass spectrometry. Sheher collaborates with academic and government researchers working on complex problems to come up with innovative, simplified workflows using the latest tools in separation and mass spectrometry.


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