The Agilent xCELLigence RTCA Cardio instrument monitors cardiomyocyte activity for cardiotoxicity assessment. The contraction-relaxation cycle of cardiomyocytes gives rise to a distinct, rhythmic fluctuation in impedance that is readily captured on the millisecond time scale. Changes in the intensity and periodicity in impedance are monitored in seconds or in days to assess cardiomyocyte contractility and viability in the presence of various drugs. The Agilent xCELLigence RTCA Cardio instrument analyzes cells in an electronic 96-well plate format (E-Plate Cardio 96), which are placed in a standard CO2 cell culture incubator and interface via a cable with analysis and control units that are housed outside the incubator.
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