Agilent Seahorse XFe24 Analyzer

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Agilent Seahorse XFe24 Analyzer

The Agilent Seahorse XFe24 Analyzer measures the oxygen consumption rate (OCR) and extracellular acidification rate (ECAR) of live cells in a 24-well plate format. OCR and ECAR rates are key indicators of mitochondrial respiration and glycolysis as well as ATP production rate, and together these measurements provide a systems-level view of cellular metabolic function in cultured cells and ex-vivo samples.

Features

Live cell, real-time analysis of cellular energy metabolism platform in 24-well format.
Multiple parameters reported from each assay well, including OCR, PER or ECAR, and ATP product rates.
Large well size and transient microchamber to provide the capacity for larger and/or more metabolically active samples.
Robust response with as few as 10,000 cells per well in the custom 24-well plate.
Compatible with 3D study models such as islets and small organism (for example, zebrafish).
Four-port injection system with automated mixing feature for assessing immediate cellular responses to substrates, inhibitors, and other compounds in real time.
Wide operation environment temperature of 4 to 30 °C, allowing the analyzer to maintain internal assay temperature of 16 to 42 °C for compatibility with a variety of samples.
Data files compatible with the web-based analytics tool, namely, Seahorse Analytics.

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Applications

Immunology Research (e.g. determining metabolic fitness of immune cells, measuring and modulating immune cell activation in real time and targeting metabolic pathways to improve immunotherapy design and performance)
Cancer Research (e.g. rewiring metabolism to support rapid growth, understanding which nutrients fuel cancer cells and uncovering how metabolism impacts the tumor microenvironment)
Toxicology Research (e.g. detecting mitochondrial liabilities among potential therapeutics, assessing the risk of mitochondrial toxicity in vitro with high specificity and sensitivity and determining the mechanism of action of mitochondrial toxicants)
Obesity, diabetes, and metabolic disorders research (e.g. measuring functional effects of genetic changes to metabolic pathway components, examining nutrient use in healthy and diseased cell models and assessing fatty acid oxidation and glycolysis in different cell types)

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Specifications

Agilent Seahorse XFe24 Analyzer

Features

Videos

Applications

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