Chromatograpahy & Mass Spec

Since most samples encountered in a chromatography laboratory are not in a form to be directly placed into the analytical instrument, some form of preparation is required for nearly every sample. The sample preparation could be as simple as “dilute and shoot” or as complex as multistage sample handling. The aim of sample preparation is to provide a sample aliquot that (a) is relatively free of interferences, (b) will not damage the column or instrument and (c) is compatible with the intended analytical method. In chromatography, the sample solvent should dissolve in the HPLC mobile phase or be injectable into a GC column without affecting sample retention or resolution, the stationary phase itself, and without interfering with detection. 

Fundamentals

Here you can find useful resources on Sample Preparation for Chromatography Techniques

Sample Preparation Fundamentals for Chromatography

Primer

Simple Approaches to SPE Method Development

Simple Steps to Maximize Lipid Removal with EMR-Lipid