A Look at Data Integrity in Pharma Labs

Data integrity problems in pharmaceutical quality control laboratories are driving more regulatory action than ever before. What has changed to drive all this activity? While plenty of information is available, much of it seems to confuse rather than clarify.

Data integrity is a critical aspect in pharmaceutical laboratories, ensuring that the data generated during business operations and drug manufacturing is accurate, complete, and reliable. When data is reliable, business owners can make informed decisions, improve product quality, and contribute to overall success.

Data integrity is important because it builds trust with stakeholders and ensures that the information used to evaluate drug safety, efficacy, and quality is trustworthy. For patients using a pharmaceutical product, it assures them of the safety that is promised and provides qualitative evidence to support the manufacturer’s guarantee.

As W.E. Deming said,

“Without data, you are just another person with an opinion.”

Let’s explore some common myths of data integrity by looking at facts, based on a study of available resources and direct interactions with U.S. Food and Drug Administration (FDA) staff and their consultants.

 

Myth: All this regulation around data integrity is new

Data integrity has been a concern for decades. The FDA’s focus on it began with 21 CFR Part 11 in 1998. In 2003, after the pharmaceutical industry spent years struggling with the regulation, the FDA released its Scope and Application guidance, clarifying some of the requirements in Part 11. This guidance also included a discussion of the FDA’s selective enforcement strategy based on what the administration was finding during its inspections. In 2010, the FDA announced its focus on data integrity inspections. At that time, however, few people within the FDA were qualified to understand the data integrity aspects of computerised systems. Thus, beginning in 2013, data integrity has been a primary inspection point, and there has been a visible increase in data integrity enforcement across all geographies. In addition, starting in 2014, as a result of those inspections, the FDA has often included the names of hardware and software products in their warning letters and related public information documents in a less than subtle message to the hardware and software makers that the administration expects them to assist customers with data integrity and compliance concerns.

 

Myth: Data integrity is an IT issue

Success in addressing data integrity relies less on technology and more on fostering a culture, organisation, and mindset conducive to excellence. Key contributors to effective data integrity solutions include a shared vision of data integrity practices and a commitment to continuous improvement. In both paper-based and electronic systems, data integrity issues can arise, each presenting unique challenges and requiring tailored remediation strategies. Many responses to these issues overlook the possibility of such occurrences in paper-based systems, failing to conduct risk assessments or identify areas for remediation. Compliance and best practices must span data generation, transformation, maintenance, accuracy, and consistency. Cultivating the right culture, assembling capable teams, ensuring transparency in data integrity performance, and aligning company goals with data integrity objectives are all essential components of a successful data integrity initiative.

 

Myth: Only the software needs to be compliant

Software often does not comply with regulations. The software itself is inert; software contains the technical controls to support compliance with the applicable regulations. In addition to technical controls, procedural controls must also be in place. A discussion about procedural controls versus technical controls is often seen in FDA warning letters, particularly when gaps in a system’s ability to support technical controls required by various regulations have been exploited.

A standard operating procedure (SOP), used as a procedural control, can substitute for a technical control as long as:

• People are trained on that SOP

• The SOP is followed

• Adherence to the SOP is confirmed by quality oversight and/or compliance auditing

Often, however, even if SOPs exist, they are not followed, and adherence isn’t properly verified. Consequently, the FDA will demand system remediation to prevent a recurrence of the behaviour. Audit trails within computerised systems are an example of technical controls. The software must be able to generate audit trails that contain all the components the regulations require, and then those controls must be enabled.

Analytical instrument manufacturers are taking compliance and regulations into account with their products. As an example, Agilent is applying critical thinking to redesigning laboratory software to help respond to new regulatory compliance realities. Many systems may generate audit trail reports in printed form, but the new version of the Agilent OpenLAB Chromatography Data System has a built-in tool that allows a user to electronically review electronic audit trails entries. These audit trail entries are organised by type, an online review can be performed, and electronic signatures incorporated.

Chromatography Data Systems
Chromatography Data Systems

 

If data integrity regulation compliance is a necessity for your pharma lab, Chemetrix is able to provide solutions that include instruments and software that can help ensure your data is not only well managed and organised, but kept safe and generated with adherence to all the regulatory guidelines.

Data integrity problems can severely impact business operations, leading to financial losses, legal issues, and damaged reputation. It forms the foundation of for reliable pharmaceutical research, development, and manufacturing and, therefore, should be as error-free and precise as possible. It goes beyond being just a practice; data integrity is the cornerstone of trust and excellence in pharmaceutical labs, paving the way for groundbreaking discoveries and lifesaving innovations.

 

Agilent BioTek 406 FX Microplate Washer Dispenser: Technology-Driven Application Diversity and Workflow Efficiency

Introducing Agilent BioTek’s new 406 FX microplate washer dispenser. Built on decades of innovation and success, the 406 FX is the latest advancement in microplate washing and dispensing. The 406 FX integrates parallel peristaltic and syringe pump dispensing with microplate assay washing within a singular platform. The compact design of the 406 FX delivers fast, full-plate washing along with six reagent dispensers. From basic ELISA, to sensitive cell washing, to biomagnetic bead washing, the 406 FX offers modules to address a myriad of assay requirements and workflows.

The automated microplate dispensers perform across a range of volumes offering simple, repeatable, and precise liquid delivery. Modular peristaltic and syringe pump dispensers help to meet varied liquid handling requirements, catering to the broadest spectrum of assay workflow requirements. This multidisciplinary tool enables researchers to drive a diverse spectrum of applications while maintaining workflow efficiency.

 

Speaker

Dr. Charles William Amirmansour
Global Business Development Manager
Agilent Technologies, Inc.

Dr. Amirmansour is a Global Business Development Manager (Cell Analysis Division at Agilent BioTek) who offers a unique set of skills, creating cutting-edge business development programs, with an extensive background across the Life Science and Drug Discovery domain. Additionally, his strong academic and industry experience resonates with research-based microplate and assay technologies. His academic career started when he received his undergraduate degree at King’s College London (University of London) whilst gaining research experience at The William Harvey Research Institute (Queen Mary University of London) under the supervision of Nobel Laurate, Prof. Sir. John Vane. He then obtained his doctorate in Clinical Pharmacology from University College London (under the joint supervision of Prof. Sir Patrick Vallance and Prof. Sir Salvador Moncada). Finally, Dr. Amirmansour held two Post-Doctoral positions at The National Heart & Lung Institute and Harefield Heart Science Centre (Imperial College London), respectively under the supervision of world-renowned pioneering cardiothoracic surgeon and Lister Medal awardee, Prof. Sir Magdy Yacoub.

 

Register now >

 

A Compelling Look at Liquid Handling for Microplate Assays

Microplate assays play a crucial role in scientific research and diagnostics. By allowing researchers to perform high-throughput screenings efficiently, the method becomes essential for large-scale experiments, such as drug discovery, where thousands of compounds need to be tested rapidly.

In many microplate-based assays, there is a crucial wash step that plays a significant role in sample preparation and data accuracy.

During the wash step, the fluid (such as reagents, buffers, or unwanted substances) in the microplate well needs to be removed. This process is called aspiration. After aspiration, the microplate well is emptied of the original fluid. Now, it’s time to add a replacement fluid (e.g., a fresh buffer, a specific reagent, or a washing solution). The process of adding the replacement fluid is called dispensing.

The aspiration and dispense steps are critical for maintaining the integrity of microplate-based assays, ensuring accurate results, and optimising workflow efficiency. These labour-intensive procedures can be efficiently automated using instruments that can both wash and dispense reagents on a single hardware platform.

Complete removal or replacement of the original fluid often requires multiple iterations or cycles of aspiration and dispense. After the final aspiration of a wash protocol is completed, often the next step in the assay protocol is the addition of a specific reagent

For example, ELISA reactions are antibody-based reactions that use a series of binding reactions to quantify specific analytes. With a typical ELISA protocol, repeated cycles of microplate washing, reagent addition, and incubation are executed to add specific reagents and to remove unbound material before data collection. When performed manually, this process requires a technician to manage the timing and be available to move plates between the washer and multiple dispensers.

 

What is needed is the utility of an instrument with both washing and dispensing capabilities within the context of widely used applications.

 

The Agilent BioTek 406 FX is a modular system and is fully programmable from either its built-in touch screen or using Agilent BioTek Liquid Handling Control (LHC) software on an attached PC. The 406 FX is an automated microplate processor that can perform microplate washing steps in 96-, 384-, and 1536-well microplates. In addition to standard wash routines, the 406 FX has built-in cell-washing capabilities. An internal buffer-switching valve allows for the selection of up to four different wash buffers without changing bottles. A built-in sonicator provides the capability for automated cleaning maintenance of the dispense manifold.

Agilent BioTek 406 FX Washer Dispenser

 

There are compelling reasons for wanting to make use of a single instrument for these functions. Having both functions in one instrument reduces the need for manual intervention and minimises the time spent switching between different devices. This can improve workflow which then also improves efficiency. A single instrument saves space and is often more cost-effective than buying separate washers and dispensers. Finally, integrated liquid handlers ensure consistent aspiration and dispensing techniques across all wells. This consistency improves data quality and reduces variability.

The advantages of an instrument like Agilent BioTek 406 FX create opportunities for labs to not only improve their operations, it also allow them to offer high-quality analysis output, greater accuracy, and cost-effectiveness. Chemetrix is able to work with your lab to determine the best solution for your needs and ensure that your liquid handling requirements are fulfilled. Speak to one of our consultants today.

 

Ensuring the Sweet Integrity of Honey Quality with Randox Food Testing Solutions

Honey is a beloved golden elixir that is seeing a growing demand worldwide. As one of nature’s food wonders, this natural sweetener is big business and the international trade of honey is worth over 2 billion dollars.

Its sweet taste and myriad of health benefits mean honey holds a special place in the hearts of consumers worldwide. However, the rise in demand for this natural sweetener has led to increased instances of adulteration, where inferior or artificial substances are added to bulk up volumes or enhance appearance. The need for robust quality assurance measures has never been greater if we want to ensure the integrity of the honey industry and maintain the delicate symbiotic relationship between humans and the honey bee.

 

Honey That’s Not Quite Honey

Adulteration in honey refers to the deliberate addition of substances, such as sugar syrups or other sweeteners, to honey with the intent to deceive or manipulate its quality, composition, or appearance. This practice is often carried out to increase profits by diluting pure honey with cheaper ingredients or enhancing its colour and texture to mimic higher-quality varieties.

Adulteration can compromise the authenticity, nutritional value, and sensory attributes of honey, posing risks to consumer health and safety. Detection and prevention of adulteration are essential to maintain the integrity and reputation of honey products in the marketplace.

With a commitment to innovation, integrity, and customer satisfaction, Randox empowers producers to uphold the highest standards of purity and authenticity in their honey products, ensuring consumer trust and market success.

For producers looking to export their honey with confidence, there are solutions available for safeguarding the purity and integrity of this cherished commodity every step of the way.

 

Keeping Honey Bees Healthy

An important pillar of honey quality control is the utilisation of exposomics, a holistic framework that examines the impact of environmental exposures on human health. Exposomics is the study of the comprehensive set of environmental exposures and stressors that impact the well-being and resilience of honey bee colonies.

This approach encompasses various factors, including pesticides, pathogens, pollutants, climate change, habitat loss, and nutritional stressors, among others. By examining the complex interactions between honey bees and their environment, exposomics aims to understand the cumulative effects of these exposures on bee health, colony dynamics, and population decline. Through advanced analytical techniques and interdisciplinary research, exposomics offers insights into strategies for mitigating stressors and promoting the resilience of honey bee populations in the face of environmental challenges.

Watch our webinar on Using Exposomics to Improve Honey Bee Health here >

 

Championing Honey Integrity

As a brand that cares about global honey quality, Randox Food Testing is a beacon of reliability and excellence, offering comprehensive testing solutions and unparalleled expertise to honey producers worldwide. Leveraging cutting-edge technologies and innovative solutions, Randox offers solutions designed to detect and prevent adulteration, ensuring the purity and authenticity of honey products.

Chemetrix equips food producers with the tools they need to safeguard their honey supply chain from farm to fork. Through advanced techniques such as the Randox Biochip Array technology through to our LC-TOF MS from Agilent Technologies, we enable producers to achieve unparalleled levels of traceability and transparency, instilling confidence in consumers and regulatory authorities alike.

This trusted name in analytical instruments understands the need for honey to remain as close to an all-natural product as possible without drug residues and other contaminants affecting its quality. That’s why their products are ideal for honey testing including antibiotics, pesticides and a range of quality tests such as sucrose, glucose/fructose, HMF and Diastase. Biochip Array Technology is ideal for the screening of multiple antimicrobials within honey, up to 54 samples in just 2 hours 30 minutes.

We also offer a variety of TOF LC/MS instruments like the Agilent 6230B TOF LC/MS. Contact one of our consultants for more information.

 

Empowering Honey Producers

There are lots of resources and educational opportunities for honey producers looking to enhance their understanding of quality assurance practices. Randox has webinars, seminars, and educational materials that offer insights into emerging trends, regulatory updates, and best practices in honey production and testing.

 

As a supplier of Randox instruments and products on the African continent, Chemetrix serves as a conduit to ensure honey producers have access to the best testing and analysis solutions available. We are committed to safeguarding the purity and integrity of this cherished commodity every step of the way and helping honey producers guarantee the quality of their products. With some of the world’s best lab equipment available, we can all be part of a culture of continuous improvement and innovation, driving excellence in honey quality control across the industry.

 

Ensuring the Sweet Integrity of Honey Quality

Honey is a beloved golden elixir that is seeing a growing demand worldwide. As one of nature’s food wonders, this natural sweetener is big business and the international trade of honey is worth over 2 billion dollars.

Its sweet taste and myriad of health benefits mean honey holds a special place in the hearts of consumers worldwide. However, the rise in demand for this natural sweetener has led to increased instances of adulteration, where inferior or artificial substances are added to bulk up volumes or enhance appearance. The need for robust quality assurance measures has never been greater if we want to ensure the integrity of the honey industry and maintain the delicate symbiotic relationship between humans and the honey bee.

 

Speaker

Dr. Liberty Sibanda
RandoxFood Diagnostics

 

Watch now >

 

Speakers

Dr. Christopher Mayack
Swarthmore College, Department of Biology


Dr. Robert L. Broadup

Haverford College, Department of Chemistry

 

Register now >

 

Best of Imaging Applications

Cell culture lies at the heart of many biological studies, serving as a foundational technique for a myriad of applications, from basic research to drug discovery. Register for this exciting webinar that will explore the newest features and instrument capabilities supporting kinetic live-cell imaging, from real-time analysis of rapid GPCR signalling pathways to long-term treatment-induced effects on cell proliferation and viability.

 

Speaker

Joe Clayton, PhD
Scientific Program Manager,
Agilent Cell Analysis

 

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Unlocking the Potential of Automated Imaging Tools in Cell Culture and Assay Development

In the dynamic landscape of cell biology research, advancements in technology continually reshape our understanding of cellular processes and pave the way for innovative discoveries. Automated imaging tools stand at the forefront of this revolution, offering researchers valuable insights into improving routine cell culturing techniques and enhancing the effectiveness and reproducibility of downstream cell-based assays.

Automated imaging tools help researchers learn more about how to make cell culturing better and how to improve the accuracy and consistency of cell-based tests. Unlike traditional manual methods, which are prone to subjectivity and variability, automated imaging offers an objective, quantitative analysis of cellular parameters in real time.

This level of precision and consistency is essential for optimising cell culture conditions, evaluating the efficacy of experimental treatments, and ensuring the reproducibility of results across experiments. Additionally, high-content imaging capabilities enable researchers to multiplex their analyses, simultaneously probing multiple cellular features within the same sample. This holistic approach not only enhances the efficiency of assay development but also allows for a more comprehensive assessment of cellular responses to various stimuli.

Overall, automated imaging tools empower researchers to unravel the complexities of cellular processes with unprecedented accuracy and throughput, driving innovation and accelerating discoveries in cell biology.

 

Enhancing Cell Culturing Techniques with Automated Imaging

Cell culture lies at the heart of many biological studies, serving as a foundational technique for a myriad of applications, from basic research to drug discovery. However, traditional methods of assessing cell health and behaviour often rely on subjective observations and manual interventions, leading to variability and inefficiencies. Enter BioTek’s LionHeart FX, which can revolutionise cell culture workflows by providing real-time, quantitative data on cell morphology, viability, and proliferation. BioTek Lionheart FX allows you to capture, process, analyse, annotate images, and produce videos with ease. By automating image acquisition and analysis, researchers can gain deeper insights into cellular dynamics, optimise culture conditions, and ensure reproducibility across experiments.

Agilent BioTek Lionheart FX Automated Microscope

 

Empowering Assay Development

The effectiveness of cell-based assays hinges on the accuracy and reliability of the data obtained. BioTek’s Cytation emerges as a game-changer, offering high-content imaging capabilities that enable multiplexed analysis of cellular parameters in a single experiment. Digital microscopy and multimode detection deliver both phenotypic data and quantitative data from one instrument, maximising laboratory productivity. With its automated imaging and image analysis features, Cytation streamlines assay development accelerates screening processes and enhances the robustness of downstream assays, ultimately driving efficiency and productivity in research endeavours.

Agilent BioTek Cytation C10 Confocal Imaging Reader

 

Optimising Workflow Efficiency with Integrated Liquid Handling

Liquid handling is a critical aspect of cell culture and assay development, where precision and accuracy are paramount. Manual pipetting procedures not only pose a risk of human error but also limit throughput and scalability. In this regard, BioTek’s MultiFlo FX delivers unparalleled flexibility and efficiency by integrating automated liquid handling with imaging capabilities. Whether dispensing media, performing cell-based assays, or conducting plate washing steps, MultiFlo FX streamlines workflows, minimises hands-on time, and ensures consistent results, empowering researchers to focus on data analysis and interpretation.

Agilent BioTek MultiFlo FX Multimode Dispenser

 

Embracing the Future of Cell Biology with BioTek

In the rapidly evolving field of cell biology, leveraging state-of-the-art technology is essential for driving innovation and pushing the boundaries of scientific discovery.

 

BioTek’s Cell Analysis instruments represent a beacon of innovation, offering researchers a comprehensive suite of tools to elevate their research to new heights.

 

Smart Lab Design: Maximising Space and Efficiency

Thanks to film and television, everyone thinks labs are generous spaces filled to the brim with the latest equipment. In the reality of the world of scientific discovery, where breakthroughs are born from the confines of laboratories, the paradox of limited space presents a unique challenge. The quest for efficient and innovative smart lab designs becomes imperative, transforming constraints into opportunities for creativity and optimisation.

 

The significance of space optimisation in lab design

Lab spaces, often regarded as the epicentres of innovation, are not immune to the constraints of real estate. The importance of space optimisation in lab design cannot be overstated, especially when faced with the challenges of limited square footage. Efficient use of space directly impacts workflow, collaboration, and the overall productivity of the lab.

Even the science world isn’t immune to the fact that rising operational costs for businesses means lab space costs more and budgets might not allow for that extra room. New labs just starting out might have a small space to work with and grow from there but it gives them a chance as well to find an efficient layout for business growth.

Maximising limited lab space

Having less space doesn’t have to be a big hurdle for a lab to overcome. With thoughtful planning and strategic design, it’s possible to make the most out of every available square meter. Here are some practical ideas to address the challenge:

1. Modular furniture: Opt for modular and flexible furniture that can be easily rearranged to accommodate changing research needs. This adaptability ensures that the lab layout can evolve without major renovations. Bench space that has wheels and clips means the configuration can be altered as the lab changes.

2. Vertical storage solutions: Utilise vertical space for storage. Shelving, cabinets, and other storage solutions that extend upward maximise storage capacity without encroaching on valuable floor space.

3. Shared workstations: Implement shared workstations and collaborative areas to reduce the need for individualised spaces. This fosters a sense of community and optimises the usage of available space.

4. Streamlined equipment selection: Choose compact and multi-functional equipment. Advances in technology have led to the development of instruments that offer robust performance while minimising the physical footprint.

Perfect examples of space-saving equipment include the Agilent Cary 630 FTIR Spectrometer, the world’s smallest FTIR, and the Agilent 5900 ICP-OES, which is the smallest ICP-OES on the market.

 

Innovative lab layouts and new instruments

Rather than viewing limited space as a hindrance, consider it an opportunity for innovation. Novel lab layouts that prioritise collaboration and flexibility can emerge from the constraints of space limitations.

Embrace open-concept designs, shared spaces, and fluid workstations that encourage dynamic interaction among researchers. Additionally, explore the latest advancements in analytical instruments designed specifically for compact labs. Instruments that integrate seamlessly, require minimal space and deliver optimal performance are key to navigating the challenges of limited lab space.

Space-saving solutions with Chemetrix

The quest for efficient lab design in small spaces is not just a practical necessity; it is an opportunity for creative solutions and innovative layouts. By adopting smart lab designs and leveraging space-saving instruments, laboratories can transcend the limitations of physical space, fostering an environment where groundbreaking discoveries thrive.

As laboratories embark on the journey to optimise their limited space, exploring space-saving analytical instruments becomes a critical step. Chemetrix offers a comprehensive portfolio of instruments designed to be user-friendly, integrate seamlessly with existing systems, and maximise efficiency within confined lab spaces. To unlock the potential of space-saving solutions tailored to your lab’s unique needs, contact Chemetrix today. Together, we can redefine the boundaries of innovation, even in a small space.

Become a Better Chromatographer Webinar Series

Whether you are a seasoned GC veteran or a beginner, this GC Webinar series will help to make you a better chromatographer so you get the reproducible results you need to make your lab more productive.

 

 

Overwhelmed with too many GC column options? Let us help

There are many column choices for GC and GC/MS, but which one is right for your method? Choosing the correct column type is paramount in being successful with your analysis. Understanding the stationary phase chemistry and the role it plays in column selectivity, as well as the dimensions of the capillary column itself, will result in a more robust and efficient analysis. This talk will discuss how the various stationary phases influence selectivity, as well as how column dimensions affect peak behavior and resolution. Join us as we match you with the right column for your analysis!

Speaker

Mark Sinnott
Application Engineer
Agilent Technologies, Inc.

 

 

 

Analysis of Permanent Gases: More Challenging Than You Might Think

On the surface, this would appear to be a simple separation—however, there are several challenges related to the analysis of permanent gases. We will discuss typical techniques for resolving and detecting permanent gases, including carbon dioxide and hydrogen. Other topics will include cryogenic techniques, column isolation, and the use of the Agilent J&W Select Permanent Gases/CO2 GC column.

Speaker

Mark Sinnott
Application Engineer
Agilent Technologies, Inc.

 

 

Take the Trouble Out of Troubleshooting: Gas Chromatography

We probably have all experienced this at some point when performing gas chromatography—our peak shape begins to appear a bit different. In this webinar, we will discuss some of the most common chromatographic issues that you experience with gas chromatography and take a logical approach to finding the root cause and correcting the problem. Often the best way to approach troubleshooting is to also consider what cannot cause an issue so that precious time is not spent addressing something that is not relevant to the symptoms. This webinar will arm you with simple tools, and a different way to look at troubleshooting, should a problem arise.

Speaker

Alex Ucci
Application Engineer
Agilent Technologies, Inc.

 

 

Agilent GC/MS Solutions for Cannabis and Hemp Testing

This presentation will introduce you to the Agilent flow path solutions for residual solvents, terpenes, and pesticide testing in cannabis and hemp. We will discuss how we have made it easier for you to get up and running quickly with e-Methods, application notes, and consumable kits.

Speaker

Simon Jones
GC Applications Engineer/Scientist
Agilent Technologies, Inc.

 

 

Keep your GC Column Alive: Tips and Tricks for Extending Column Lifetime

These are just some of the questions we receive frequently in technical support and will address in today’s webinar.  We will show you some tips and tricks on how to bring your column back to life as well as when it is time to get a new one.  We will also discuss some preventative measures you can take to keep your column healthy such as implementing sample preparation.

Speaker

Ryan Birney
Application Engineer
Agilent Technologies, Inc.

Alex Ucci
Application Engineer
Agilent Technologies, Inc.

 

 

Demystifying Valve Gas Chromatography: Understanding Complex Valve Configurations

Valve chromatography can be overwhelming to even the most experienced GC users.  Join us as we discuss the physical design of the valves, how the physical design relates to common valve diagrams, and common uses for different types of valves.  We will begin with simple valve configurations and understand how these simple concepts can create a complex solution.  We hope to have you leave with a basic understanding of valve chromatography.

Speaker

Kelly Beard
Application Scientist
Agilent Technologies, Inc.

 

 

Get Better Resolution for your New Year’s Resolution: GC Separation Troubleshooting

Whether it be eating healthier or exercising more, we all set goals for the New Year.  But are you also resolving to get better resolution this year with your GC columns?

Are you experiencing peak co-elution or would you simply like to obtain more resolution between your peaks?

Join us as we discuss methods and strategies for getting better resolution as your New Year’s resolution.

Speaker

Alex Ucci
Application Engineer
Agilent Technologies, Inc.

 

 

Indecisive About your Column Selection? Let Us Help You Choose the Correct GC Column

There are many column choices for GC and GC/MS but which one is right for your method?   Choosing the correct column type is paramount in being successful with your analysis. Understanding the stationary phase chemistry and the role it plays in column selectivity, as well as the dimensions of the capillary column itself, will result in a more robust and efficient analysis. This talk will discuss how the various stationary phases influence selectivity, as well as how column dimensions affect peak behavior and resolution. Join us as we match YOU with the right column for your analysis!

Speaker

Alex Ucci
Application Engineer
Agilent Technologies, Inc.

 

 

Agilent 8890 Features to Improve Lab Productivity

Have you been wondering how the new features in the 8890 can help your lab? Do you know the new features the 8890 has to offer? The 8890 has integrated tools that can help your lab with productivity. The new tools can also help your lab maintain, troubleshoot, and monitor your GC’s usage. Join this webinar to learn more about these features and find out how you can implement them in your lab.

Speaker

Jamie Wetuski
GC Training Specialist Technical Marketing
Agilent Technologies, Inc.

 

 

Understanding GC- What is Really Going on Inside the Box?

In this presentation, we will leave you with an understanding of what Gas Chromatography really means, and what is really happening from injection to detection. We will explain what resolution is, and how to improve it as well as the influence that each component of the system has on your results in general.

Speaker

Mark Sinnott
Application Engineer
Agilent Technologies, Inc.

 

 

Making Better Connections in GC and GC/MS Systems

This presentation will cover products from Agilent that make GC connections more robust by utilizing new technologies that makes connections easier, leak free and more inert for any application.

Topics covered include: Self Tightening Stainless Column Nuts and ferrules, Press Fits, UltiMetal Plus and Stainless Steel Capillary Tubing, Ferrule Pre-swaging installation tool and MS interface installation tool, among others.

Speaker

Mark Sinnott
Application Engineer
Agilent Technologies, Inc.

 

 

Tips and Tricks: Best Practices for Column Installation and Care of GC Columns

The installation and care of your GC column is of the utmost importance. Whether you are new to the practice of gas chromatography, or would like a refresher, join us as we discuss proper column installation and handling for all Agilent GCs, including the Agilent Intuvo 9000 GC. We will also address the common modes of column degradation and some of the misconceptions that people have concerning column degradation. Lastly, we will discuss ways that you can protect and maintain your column performance and extend its lifetime while minimizing instrument downtime.

Speaker

Alex Ucci
Application Engineer
Agilent Technologies, Inc.

Ryan Birney
Application Engineer
Agilent Technologies, Inc.

 

 

Techniques for Avoiding Unexpected Problems in LC and GC Analysis

Chromatography can be complicated. Sample preparation is important, but not always used correctly. This webinar will cover some unexpected problems and solutions to generate better data. We will cover topics including peak shape, ghost peaks, tailing peaks, split peaks, missing peaks, variable retention times, high backpressure, instrument contamination, and ion suppression. We will go over strategies for cleaning up your sample, protecting your column and instrument from sample matrix contamination, and getting reliable, reproducible, and accurate results from your chromatography.

Speaker

Alex Ucci
Application Engineer
Agilent Technologies, Inc.

 

 

How to Go Fast and Make Your Carrier Gas Last

In today’s ever-changing laboratory environment, sample throughput and security of supply are paramount in maintaining productivity. With the recent limited availability and cost increase of helium, many labs are looking at ways to conserve and convert. In this webinar, we will demonstrate how simple column and consumables choices can improve speed of analysis, while also minimizing the use of carrier gas. We will also illustrate how these same consumables will provide the flexibility needed to simplify conversion to hydrogen carrier gas, if needed. Finally, we will provide some simple, under-utilized tips on how to conserve your current gas use. Please join us to hear how you can implement fast GC methods that will also reduce the impact of carrier gas supply disruptions.

Speaker

Ashlee Gerardi
Product Marketing
Agilent Technologies, Inc.

 

 

How to Keep a Good Thing Going: Preventive and Routine Maintenance for Your GC System

There are many consumables in the GC flow path, and sometimes it can be tricky to know when it is time for a replacement. Join us as we review the common consumables in the GC flow path and point out common signs or symptoms that indicate it may be time to do some maintenance.

Speaker

Alex Ucci
Application Engineer
Agilent Technologies, Inc.

 

 

Unlocking Pesticide Analysis Excellence: Proven Tactics for Optimal Results with Helium and Hydrogen

Delve into the GC/TQ pesticide analysis workflow, from sample preparation to robust results over hundreds of injections. We will uncover the expert strategies for enhancing analytical performance in the analysis of pesticides in challenging food matrices with the 7000E GC/TQ and the 7010C GC/TQ. From EMR pass-through cleanup to the benefits of a midcolumn backflush, GC injection optimization, column considerations with helium and hydrogen, GC method translation, retention time locking, and the consumables designed to simplify the setup, we will reveal the keys to success with both helium and hydrogen carrier gases. Elevate your analysis with tips and tricks that bring out the best in your results.

Speaker

Anastasia A. Andrianova
GC/MS Application Scientist
Agilent Technologies, Inc.

 

 

Navigating Troubled Waters: A Deep Dive into Water Injections by GC

Injecting water into your GC may be convenient, especially if you are working with compounds that have limited solubility in organic solvents or with water samples. However, there are many potential problems with water, including injector and detector issues. Join us as we take a dive deep and explore water injections and not only how to perform them correctly, but also the many pointers to keep in mind when working with water.

Speaker

Mark Sinnott
Application Engineer
Agilent Technologies, Inc.

 

 

Don’t Get Carried Away by Carryover: Troubleshooting GC Chromatography

Have you ever seen analyte peaks show up in a blank, or extra peaks suddenly appear out of nowhere? It is likely that you have some carryover or contamination in your system. Contamination that creates ghost and carryover peaks can be introduced at different points, including sample preparation, introduction, and separation. The additional peaks can cause false positive identifications and/or inaccurate quantitative results.

Speaker

Alex Ucci
Application Engineer
Agilent Technologies, Inc.

 

 

Prevent, Protect, Purify: The Benefits of Gas Filtration

Impure gases can cause installation delays, premature instrument failure, and flawed results. Purification is one of the most important steps that you can take to optimize your system performance. Although you might purchase the highest-quality gas, purification still acts as a form of insurance in case a leak occurs. Join us as we cover options for gas purification and have a look at what gas contamination looks like so you can spot it in your chromatography.

Speaker

Ryan Birney
Application Engineer
Agilent Technologies, Inc.

 

 

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Spectroscopy Digital Workshops & Bootcamps Webinar Series

Hone your lab skills, outside the lab, with our live, interactive series of virtual workshops and software bootcamps! Learn about the latest in software solutions for Spectroscopy, discuss the entire analytical process from method development to data analysis, and participate in live analytical runs with our experts. We hope these will prepare you for future hands-on events in the future.

 

 

From Single Cell and Nanoparticle Analysis to Laser Ablation and Beyond: Advanced ICP-MS Research Applications

This discussion will include an overview of NanoParticle, Single Cell, Speciation, Laser Ablation, and other hyphenated ICP-MS applications that can advance your research and development with unparalleled insights.

Speaker

L. Craig Jones
ICP-MS Application Scientist,
Agilent Technologies, Inc.

 

 

Microplastic Pollution: IR Microspectroscopy is Enhancing Chemical Identification

Speaker

Dave Schiering
Founder & Chief Technology Officer
RedWave

 

 

Tips and Tricks Workshop on ICP-OES: Smarter Method Development

Techniques on how to achieve the best sensitivity and detection limits through tuning techniques and strategies.

Speakers

Ana García González
Atomic Spectroscopy Application Scientist
Agilent Technologies, Inc.

Christopher Conklin
Product Specialist
Agilent Technologies, Inc.

 

 

Microplastics in Wastewater: A Population-Based Approach to Identifying Potential Sources

Speaker

Ian Eggleston
Masters Student in Plant and Soil Sciences
Stockbridge School of Agriculture, UM, Amherst

 

 

Innovations in ICPMS Software: Making the Most of Your Analysis

Recent innovations in ICPMS MassHunter and how these innovations can assist analysts be more confident in their data.

Speaker

Bert Woods
Application Scientist
Agilent Technologies, Inc.

 

 

Moving from R&D and Limited QC on a UV-Vis-NIR instrument to Large Scale QC Using an Autosampler

Speaker

Mark Fisher, PhD
Application Engineer, Molecular Spectroscopy
Agilent Technologies, Inc.

 

 

Tips and Tricks on ICP-OES for Best Detection Limits and Less Carryover

When it comes to detection limits we all want to achieve the lowest possible values. Learn all the tips and tricks and select the proper components of an ICP-OES sample introduction system to optimize your data quality. Take advantage of the smart and easy features of Agilent’s ICP-Expert software to enhance instrument performance and remove carryover.

Speaker

Sima Singha, PhD
ICP-OES Application Scientist, Atomic Spectroscopy
Agilent Technologies, Inc.

 

 

Identification of Incoming Raw Materials in Paper Bags, Sacks, Tubs, Bottles, and Barrels

Speaker

Luciana Terra
Application Scientist, Molecular Spectroscopy
Agilent Technologies, Inc.

 

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